Research Documented Splash-back

Splash-back has been previously reported upon in scientific studies. A 1966 article titled, Vaccination by Jet Injection, published in the British Medical Journal stated, “There is no risk of cross-infection unless the face of the injector is contaminated with blood or tissue juices” (Anonymous, 1966). Although studies have demonstrated the nozzle of the jet injector indeed becomes contaminated during jet injection.

  • Hoffman and colleagues (2001) observed the nozzle and internal fluid pathway became contaminated during the jet injection process amongst several brands of jet injectors, including the Ped-O-Jet and Med-E-Jet. He termed this phenomena as ballistic contamination, whereupon the force of impact caused a release of pressure which expelled debris away from the site of impact (Voelker, 1999). With the jet injector being directly behind the site of impact it is a prime target to becoming contaminated.
  • Lipson and colleagues (1958) assessed if the antibody response to a poliomyelitis vaccine via jet injection would be comparable to needle and syringe. In the study, thirty-four children received two doses of polio vaccine via a handheld Press-O-Jet injector and twenty-seven children received one dose of vaccine by needle. Lipson stated, “We observed blood on the nozzle of the jet injector on two different occasions.” This means in 3 percent of the injections blood was observed on the jet injector nozzle, indicating the nozzle became contaminated due to splash-back.
  • Kutscher and colleagues (1962) warned of splash-back within their paper. “The Hypospray unit itself is not sterilized although the head can and should be disinfected,” stated the researchers. If the patient’s arm is not properly held “some portion of the injected material may rebound and not attain its target” (emphasis added). In other words the injected material would splash back onto the jet injector.
  • Dr. Sol Roy Rosenthal studied the transference of blood via the Hypospray Multidose jet injector amongst children at two schools. Observations from the first school found the jet injector produced “much bleeding.” Overall the study found in 17 percent of the vaccinations of school children there was enough blood on the jet injector nozzle to transmit blood-borne pathogens (Rosenthal, 1967).
  • Horn, Opiz and Schau (1975) observed splash-back through their investigations of the Hypospray Multidose and warned of the risk this posed in spreading hepatitis. Horn stated,

We were able to demonstrate by direct staining of material obtained from the nozzle, that this part of the injector becomes contaminated with material originating in human white blood corpuscles. These findings are very similar to those of Hughes with syringes and have an obvious implication in relation to the transfer of hepatitis virus by jet injectors (Horn, Opiz & Schau, 1975).

This research serves as evidence that the nozzle face of the jet injector becomes contaminated during the injection process.



  • (Anonymous, 1966) Anonymous. Vaccination by Jet. Br Med J December 31, 1966: 1610.
  • (Hoffman et al., 2001) Hoffman PN, Abuknesha RA, Andrews NJ, Samuel D, Lloyd JS. A model to assess the infection potential of jet injectors used in mass immunization. Vaccine 19 (2001): 4020-4027.
  • (Horn, Opiz & Schau, 1975) Horn H, Opiz B, Schau G. Investigations into the risk of infection by the use of jet injectors. Health and Social Serv J 85:2396–2397, 1975.
  • (Kutscher et al., 1962) Kutscher AH, Hyman GA, Zegarelli EV, Dekis J, Piro JD. A comparative evaluation of the jet injection technique (Hypospray) and the hypodermic needle for the parenteral administration of drugs: a controlled study. Am J Med Sci 1962;54:418-420.
  • (Lipson et al., 1958) Lipson MJ, Carver DH, Eleff MG, Hingson RA, Robbins FC. Antibody response to poliomyelitis vaccine administered by jet injection. Am J Public Health 1958;48(5):599-603.
  • (Rosenthal, 1967) Rosenthal SR. Transference of blood by various inoculation devices. Am Rev Respir Dis. October 1967; 96(4):815-819.
  • (Voelker, 1999) Voelker R. Eradication Efforts Need Needle-Free Delivery. JAMA May 26, 1999;281(20):1879-1881.


© Shaun Brown and Jet Infectors, 2016 – 2018
Fair Use Notice (17 U.S.C. § 107)

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